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Spanish to English: Psoriasis Paper General field: Medical
Source text - Spanish 8 Methoxypsoralen sumado a Fototerapia UVA actúa inhibiendo el eje IL 23/ Th17 e induce Foxp3 Células T reguladoras CTLA4 que participan en la señalización de trastornos de la piel Psoriasica
Resúmen
Con el fin de dilucidar la acción molecular del 8-metoxipsoraleno y UVA (PUVA), una terapia dermatológica estándar, se utilizó K5.hTGF-beta1 en ratones transgénicos que exhiben un fenotipo cutáneo y citoquinas anormales muy similares a las observadas en pacientes psoriásicos. Observamos que la alteración de la función de CD4 ( ) CD25 ( 25) en células T reguladoras (Tregs) y el aumento de los niveles de citoquinas de la vía IL-23/Th17, fueron los responsables del fenotipo psoriásico en éste modelo de ratón. LA utilización de K5.hTGF-beta1 en ratones transgénicos con PUVA suprimió la vía IL-23/Th17, mediado por Th1, así como los factores de transcripción STAT3 y el receptor nuclear huérfano ROR gammat. PUVA indujo por la vía de Th2 e IL-10 la producción de CD4 ( ) CD 25( ) Foxp3 ( ) Tregs con actividad supresora de la enfermedad, la cual fue suprimida por el anticuerpo monoclonal anti-CTLA4 mAb. Estos hallazgos fueron acompañados por estudios macroscópicos y microscópicos de la piel del ratón enfermo. El tratamiento Anti-IL-17 mAb también logró disminuir el fenotipo psoriásico de los ratones. Esto indicó que tanto la participación de células T reguladoras CTLA4 como la inhibición de la IL-23/Th17 son el eje central para la acción terapéutica de PUVA.
Translation - English 8-Methoxypsoralen Plus Ultraviolet A Therapy Acts via Inhibition of the IL-23/Th17 Axis and Induction of Foxp3 Regulatory T Cells Involving CTLA4 Signaling in a Psoriasis-Like Skin Disorder.
Abstract
To elucidate the molecular action of 8-methoxypsoralen plus UVA (PUVA), a standard dermatological therapy, we used K5.hTGF-beta1 transgenic mice exhibiting a skin phenotype and cytokine abnormalities with strong similarities to human psoriasis. We observed that impaired function of CD4( )CD25( ) regulatory T cells (Tregs) and increased cytokine levels of the IL-23/Th17 pathway were responsible for the psoriatic phenotype in this mouse model. Treatment of K5.hTGF-beta1 transgenic mice with PUVA suppressed the IL-23/Th17 pathway, Th1 milieu, as well as transcription factors STAT3 and orphan nuclear receptor RORgammat. PUVA induced the Th2 pathway and IL-10-producing CD4( )CD25( )Foxp3( )Tregs with disease-suppressive activity that was abolished by anti-CTLA4 mAb treatment. These findings were paralleled by macroscopic and microscopic clearance of the diseased murine skin. Anti-IL-17 mAb treatment also diminished the psoriatic phenotype of the mice. This indicated that both induced Tregs involving CTLA4 signaling and inhibition of the IL-23/Th17 axis are central for the therapeutic action of PUVA.
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Years of experience: 18. Registered at ProZ.com: Apr 2011.
Born in Buenos Aires, Argentina, to a bi-lingual family, I grew up speaking English and Spanish. I spent most of my childhood in Tucumán, where I later enrolled in the University to study Pharmacy. Three years later, and having very good grades, I dropped out from that career since I felt it was not my true call. Considering that I had always been good languages, I decided to study translation, and finished the career with an outstanding GPA. Later on I would graduate from 2 other careers related to languages: Bachelor in English and Sworn Translator.
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