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English to Greek: Medical abstract Detailed field: Medical (general)
Source text - English Antibody-secreting hybrid cells have been derived from a fusion between mouse myeloma cells and spleen cells from a mouse
immunized with membrane from human tonsil lymphocyte preparations. Hybrids secreting antibodies to cell surface antigens were
detected by assaying culture supernatants for antibody binding to human tonsil cells. Six different antibodies (called W6/1, /28, /32, /34,
/45 and /46 were analyzed). These were either against antigens of wide tissue distribution (W6/32, /34, and /46) or mainly on
erythrocytes (W6/1 and W6/28). One of the anti-erythrocyte antibodies (W6/1) detected a polymorphic antigen, since blood group A1
and A2 erythrocytes were labeled while B and O were not. Antibodies W6/34, /45 and /46 were all against antigens which were mapped
to the short arm of chromosome 11 by segregation analysis of mouse-human hybrids. Immunoprecipitation studies suggest that W6/45 antigen may be a protein of 16,000 dalton, apparent molecular weight, while W6/34 and /46 antigens could not be detected by this
technique. Antibody W6/32 is against a determinant common to most, if not all, of the 43,000 dalton molecular weight chains of HLA-A, B and C antigens. This was established by somatic cell genetic techniques and by immunoprecipitation analysis. Tonsil leucocytes bound 370,000 W6/32 antibody molecules per cell at saturation. The hybrid myelomas W6/32 and W6/34 have been cloned, and both secrete
an IgG2 antibody. W6/32 cells were grown in mice, and the serum of the tumor-bearing animals contained greater than 10 mg/ml of
monoclonal antibody. The experiments established the usefulness of the bybrid myeloma technique in preparing monospecific antibodies against human cell surface antigens. In particular, this study highlights the possibilities not only of obtaining reagents for somatic cell genetics, but also of obtaining mouse antibodies detecting human antigenic polymorphisms.
Translation - Greek Υβριδικά κύτταρα που εκκρίνουν αντισώματα παρήχθησαν μέσω της σύντηξης κυττάρων μυελώματος ποντικού και κυττάρων σπλήνας, από ένα ποντικό ανοσοποιημένο με μεμβράνη από παρασκευάσματα λεμφοκυττάρων ανθρώπινης αμυγδαλής. Τα υβρίδια που εκκρίνουν αντισώματα στα αντιγόνα της κυτταρικής επιφάνειας ανιχνεύθηκαν μετά από ανάλυση των υπερκείμενων καλλιέργειας ως προς την ύπαρξη αντισωμάτων που δεσμεύονται από κύτταρα της ανθρώπινης αμυγδαλής. Αναλύθηκαν έξι διαφορετικά αντισώματα (που ονομάζονται W6/1, /28, /32, /34, /45 και /46). Αυτά ήταν είτε έναντι αντιγόνων ευρείας κατανομής στους ιστούς (W6/32, /34 και /46) είτε κυρίως έναντι ερυθροκυττάρων (W6/1 και W6/28). Ένα από τα αντισώματα έναντι των ερυθροκυττάρων (W6/1) ανίχνευσε ένα πολυμορφικό αντιγόνο, καθώς
επισημάνθηκαν ερυθροκύτταρα της ομάδας αίματος Α1 και Α2 σε αντίθεση με εκείνα των ομάδων Β και Ο που δεν επισημάνθηκαν. Τα
αντισώματα W6/34, /45 και /46 ήταν όλα έναντι αντιγόνων που χαρτογραφήθηκαν στο βραχύ σκέλος του χρωμοσώματος 11 με ανάλυση
διαχωρισμού των υβριδίων ποντικού-ανθρώπου. Μελέτες ανοσοκατακρήμνισης υποδηλώνουν ότι το αντιγόνο W6/45 μπορεί να είναι μια πρωτεΐνη βάρους 16.000 dalton, φαινομενικό μοριακό βάρος, ενώ τα αντιγόνα W6/34 και /46 δεν μπόρεσαν να ανιχνευθούν με την τεχνική αυτή. Το αντίσωμα W6/32 είναι είναι έναντι ενός αντιγονικού καθοριστή ο οποίος είναι κοινός στις περισσότερες, αν όχι σε όλες, τις αλυσίδες μοριακού βάρους 43.000 dalton των αντιγόνων HLA-A, B και C. Αυτό διαπιστώθηκε από γενετικές τεχνικές σωματικών κυττάρων και από ανάλυση ανοσοκατακρήμνισης. Τα λευκοκύτταρα των αμυγδαλών δεσμεύουν 370.000 μόρια αντισώματος W6/32 ανά κύτταρο κατά τον κορεσμό. Τα υβριδικά μυελώματα W6/32 και W6/34 έχουν κλωνοποιηθεί και εκκρίνουν και τα δύο ένα αντίσωμα IgG2.
Τα κύτταρα W6/32 αναπτύχθηκαν σε ποντικούς και ο ορός των ζώων που έφεραν όγκους περιείχε περισσότερο από 10 mg/ml μονοκλωνικού αντισώματος. Τα πειράματα απέδειξαν τη χρησιμότητα της τεχνικής του υβριδικού μυελώματος στην παρασκευή
μονοειδικών αντισωμάτων έναντι αντιγόνων της επιφάνειας ανθρώπινων κυττάρων. Ειδικότερα, η μελέτη αυτή υπογραμμίζει τις δυνατότητες απόκτησης όχι μόνο αντιδραστηρίων για τη γενετική των σωματικών κυττάρων, αλλά επίσης και της απόκτησης αντισωμάτων ποντικού που ανιχνεύουν αντιγονικούς πολυμορφισμούς του ανθρώπου.
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Years of experience: 32. Registered at ProZ.com: Dec 2001. Became a member: Dec 2014.
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