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English to Norwegian: Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease
Source text - English Increased recognition that Parkinson's disease, traditionally regarded as a movement disorder, is also associated with cognitive, behavioural, and emotional changes correlated with fronto-striatal circuit dysfunction, and has generated interest in the non-motor effects of deep-brain stimulation. Several qualitative reviews of the psychiatric and cognitive aspects of deep-brain stimulation are an indication of this interest.
Cognitive and mood disturbances seem to be reported more frequently as side-effects of stimulation of the subthalamic nucleus than of the pallidum. This observation could implicate extraneous factors, such as the greater frequency with which the subthalamic nucleus is targeted or greater attention to and awareness of neurobehavioral issues in historically later studies, which tend to assess subthalamic nucleus rather than pallidal stimulation.
Translation - Norwegian Parkinsons sykdom betraktes tradisjonelt som en bevegelighetsforstyrrelse. Imidlertid er det nå økt oppfatning om at sykdommen også kan sees i sammenheng med kognitive, atferdsbaserte og emosjonelle forandringer forbundet med forstyrrelser i fronto-striatale baner. Dette har skapt interesse for de ikke-motoriske effektene av dyp hjernestimulering. Flere kvalitative evalueringer av psykiatriske og kognitive aspekter ved STN-stimulering understreker dette.
Kognitive forstyrrelser og sinnsforstyrrelser synes å være hyppigere rapportert som bivirkninger ved stimulering av nukleus subthalamicus enn av pallium. Dette kan være relatert til andre faktorer, som at nukleus subthalamicus er hyppigere omtalt eller viet større oppmerksomhet, og bevissthet rundt nevroreaktive anliggender i studier gjort de senere år, som gjerne evaluerer STN-stimulering fremfor pallidal stimulering.
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Master's degree - University of Surrey
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Years of experience: 17. Registered at ProZ.com: Jul 2007.
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