This question was closed without grading. Reason: Answer found elsewhere
Oct 30, 2020 17:47
3 yrs ago
19 viewers *
English term
chased with
English to French
Law/Patents
Patents
chemistry, chromatography
LC-MS showed most of tert-butyl 4-((7-(tert-butylcarbamoyl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)oxy)piperidine-1-carboxylate was consumed. The resulting mixture was concentrated in vacuo, and chased with DCM several times to give the crude TFA salt of N-(tert-butyl)-5-(hydroxymethyl)-2-(piperidin-4-yloxy)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (200 mg, 0.29 mmol) as oil which was used to next step
without further workup.
The resulting mixture was evaporated in vacuo, and chased with DCM several times to give a crude N-(tert-butyl)-2-(piperidin-4-yloxy)-5Hpyrrolo[
2,3-b]pyrazine-7-carboxamide (160 mg, 0.29 mmol) as an oil which was used to next step without further workup.
without further workup.
The resulting mixture was evaporated in vacuo, and chased with DCM several times to give a crude N-(tert-butyl)-2-(piperidin-4-yloxy)-5Hpyrrolo[
2,3-b]pyrazine-7-carboxamide (160 mg, 0.29 mmol) as an oil which was used to next step without further workup.
Discussion
maybe "extracted" but not sure ..
Good luck!