select out

Spanish translation: seleccionar

17:40 Jun 3, 2008

English to Spanish translations [PRO]
Medical - Medical (general)

English term or phrase: select out

Our model uses these observations to make clinical predictions of therapy failure. We demonstrate how under-dosing and prolonged regimens select out strains, which may subsequently generate mutants with higher MICs. We identify a regimen-specific threshold vancomycin concentration below which, increasing dose leads to increased selection of VISA and treatment failure (see figure). Once above the threshold, therapy is successful. For longer dose intervals, regrowth of sensitive MRSA strains prevents eradication. Exact prediction of the threshold concentrations in vivo requires further estimation of key PD parameters, namely the slope of the concentration-kill curve and the peak Emax kill rate.CONCLUSIONS: Under-dosing and long dose interval regimens can effectively select out VISA strains. We identify an intermediate region where the inter-dosing period can give rise to considerable selection pressure and the eventual emergence of VISA

Argentina28 KudoZ activity Questions: 246 (none open) (4 without valid answers) (20 closed without grading) Answers: 3
Local time: 10:12

Spanish translation:seleccionar

Explanation:
Básicamente, las dosis aconcentraciones por debajo de la CIM y/o por períodos prolongados lo que hacen es seleccionar a las cepas más virulentas. Por seleccionar se entiende que estas cepas resistentes son las que quedan después de que las susceptibles mueren, por lo que pasan a ser dominantes en la población (y un gran problema médico :(

Selected response from:

Cristián Bianchi-Bruna
Costa Rica
Local time: 07:12

Grading comment

Genial, Cristián! Muchas gracias! Saludos!
4 KudoZ points were awarded for this answer

Summary of answers provided

5 +2

seleccionar

Cristián Bianchi-Bruna

eliminar (por selección natural)

Fernando Romero R

suprimen/descartan/descomprimen

Sandra Cravero

Discussion entries: 1

Answers

12 mins confidence:

peer agreement (net): +2

seleccionar

Cristián Bianchi-Bruna
Costa Rica
Local time: 07:12
Specializes in field
Native speaker of:

English,

Spanish
PRO pts in category: 61

Grading comment

Genial, Cristián! Muchas gracias! Saludos!

17 mins confidence:

eliminar (por selección natural)

Explanation:
http://forum.wordreference.com/showthread.php?t=37633

Reference: http://forum.wordreference.com/showthread.php?t=37633

Fernando Romero R
Specializes in field
Native speaker of: Spanish
PRO pts in category: 4

30 mins confidence:

suprimen/descartan/descomprimen

Explanation:
'out' indica otro significado, que deduzco del contexto 'strains'

Sandra Cravero
Argentina
Local time: 10:12
Works in field
Native speaker of:

Spanish

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