pericentrosomal organelle accumulation
Russian translation: перицентросомальное (или околоцентросомальное) скопление органелл
| 14:23 Nov 7, 2017 |
| English to Russian translations [PRO] Science - Biology (-tech,-chem,micro-) | |||||||
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|  Selected response from: Evgeni Kushch Ukraine Local time: 20:09 | ||||||
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| Summary of answers provided | ||||
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| 4 +3 | перицентросомальное (или околоцентросомальное) скопление органелл |
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| 3 | накопление перицентросомальных органелл |
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Answers
1 hr confidence: 
peer agreement (net): +3
peer agreement (net): +3перицентросомальное (или околоцентросомальное) скопление органелл Explanation: Имеется в виду скопление органелл вокруг или вблизи центросомы (центросом). Можно и ("более") русским языком написать: скопление органелл вокруг (вблизи) центрсоом... -------------------------------------------------- Note added at 1 hr (2017-11-07 15:37:55 GMT) -------------------------------------------------- Единственное, речь может идти и о скоплении каких-либо веществ (в случае pericentrosomal accumualtion), но здесь явно речь именно об органеллах, потому что если бы organelle относилось к pericentrosomal, pericentrosomal было бы pericentrosome скорее всего, да и вряд ли бы стали писать с pericentrosome/pericentrosomal с organelle. Вот здесь описано: White arrows indicate pericentrosomal localization of TIG3. Nuclei are stained blue. For GM130, M6PR, and rab11, all panels are red/green/blue merged images. Fig. 6A shows that GM130 (red) localizes at a perinuclear location in TIG3-negative and positive cells; however, it appears more compacted in TIG3-positive (green stain) cells. M6PR, rab11 and calnexin also appear compacted at the pericentrosomal location in TIG3-positive cells (white arrows). This is readily visualized for calnexin, by comparing the distribution shown in the red single-color image (insert) with that observed in EV-infected cells (Fig. 6A), as an intense pericentrosomal concentration of calnexin is observed in TIG3-positive cells. Second, we show that TIG3 alters microtubule and microfilament distribution and this is associated with pericentrosomal organelle accumulation. Third, in another report we are studying the distribution of TIG3 in normal human keratinocytes and these studies strongly suggest a pericentrosomal TIG3 location (not shown). Based on these findings, we argue that the major effect of TIG3 is at the centrosome and that the appearance of colocalization of TIG3 with organelle markers is an artifact due to pericentrosomal organelle clustering. https://www.researchgate.net/figure/51586846_fig6_A-SCC-13-c... TIG3 is a tumor suppressor protein that limits keratinocyte survival during normal differentiation. It is also important in cancer, as TIG3 level is reduced in tumors and in skin cancer cell lines, suggesting that loss of expression may be required for cancer cell survival. An important goal is identifying how TIG3 limits cell survival. In the present study we show that TIG3 expression in epidermal squamous cell carcinoma SCC-13 cells reduces cell proliferation and promotes morphological and biochemical apoptosis. To identify the mechanism that drives these changes, we demonstrate that TIG3 localizes near the centrosome and that pericentrosomal accumulation of TIG3 alters microtubule and microfilament organization and organelle distribution. Organelle accumulation at the centrosome is a hallmark of apoptosis and we demonstrate that TIG3 promotes pericentrosomal organelle accumulation. These changes are associated with reduced cyclin D1, cyclin E and cyclin A, and increased p21 level. In addition, Bax level is increased and Bcl-XL level is reduced, and cleavage of procaspase 3, procaspase 9 and PARP is enhanced. We propose that pericentrosomal localization of TIG3 is a key event that results in microtubule and microfilament redistribution and pericentrosomal organelle clustering and that leads to cancer cell apoptosis. https://www.ncbi.nlm.nih.gov/pubmed/21858038 Я думаю здесь можно много где прочесть: https://www.google.com.ua/search?client=opera&q="perice... |
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